A novel material of cross-linked styrylpyridinium salt intercalated montmorillonite for drug delivery.

Jing Cui,Qingqing Wang,Qufu Wei,Xiaodong Chen

doi:10.1186/1556-276x-9-378

Abstract

A facile synthesis of a styrylpyridinium salt (SbQ)/montmorillonite (MMT) via cationic exchange interactions between styrylpyridinium species (specifically SbQ) and MMT platelets is reported in this work. The SbQ-MMT solutions were irradiated under ultraviolet (UV) light for a specific time to obtain the cross-linked SbQ-MMT materials. Scanning electron microscopy and atomic force microscopy analyses revealed the structures and morphologies of MMT and modified MMT. X-ray diffraction and transmission electron microscope analyses indicated that the basal spacing increased from 1.24 to 1.53 nm compared with the pristine MMT, which proved that SbQ had interacted with MMT. Thermal gravimetric analysis curves showed that the amount of SbQ in the MMT interlayers was 35.71 meq/100 g. Fourier transform infrared spectroscopy also confirmed the intercalation of SbQ species into MMT interlayers, and UV spectroscopy was used to follow up the cross-linking of SbQ-MMT. This novel material has potential applications in drug delivery, and it can also be used as an additive to improve the mechanical properties of polymers.

Highlights

Experimental Materials 1-Methyl-4-[2-(4-formylphenyl)-ethenyl]-pyridiniummethosulphate (SbQ) was purchased from Shanghai Guangyi Printing Equipment Technology Co
In summary, a styrylpyridinium salt (SbQ) was successfully intercalated into MMT via cationic exchange interactions and were irradiated under UV light to get the cross-linked SbQ-modified MMT (SbQ-MMT)
The present study was the first to our knowledge to use SbQ to intercalate into MMT layers

Summary

Background

SbQ (a styrylpyridinium salt), similar to surfactants, is an amphiphilic sensitizer of the styrylpyridinium family [1], and it produces a very planar stacked rod-like micelle structure. The cross-linked SbQmontmorillonite (MMT) has potential applications for hydrophobic drug delivery and can be used as an additive into polymeric composites and improve the stability and mechanical properties of polymers [6,7,8,9]. A styrylpyridinium salt and MMT was used to prepare SbQ-MMT cross-linked hybrid materials by UV light irradiation. After UV light irradiation, the cross-linked SbQ may have potential applications such as hydrophobic drug delivery [5], stimuli-responsive field [14,15], and passivation layer [16]

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Discussion

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