Abstract
Yoshihara, S., A. Lindén, K. Kashimoto and S. Watanabe. A long-acting novel VIP analog in the guinea pig trachea in vitro. Peptides 19(3) 593–597, 1998.—The relaxant effect of a novel VIP analog, [Arg 15,20,21Leu 17]-VIP-Gly-Lys-Arg-NH 2 was compared with that of the original VIP in the same guinea pig trachea precontracted by carbachol in vitro. The VIP analog caused significantly and concentration-dependent relaxation similarily to the original VIP. In contrast to the original VIP, the VIP analog demonstrated a slow onset and offset of action, with more than 90% of its maximum relaxation remaining 6 h after administration. Peptidase inhibition by captopril and phosphoramidon increased the relaxant effect and duration of action for original VIP but not for the VIP analog.
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