Abstract
Funding sources: The work was supported by the Key Program of Scientific Research of Fujian Medical University (09ZD016), Natural Science Foundation of Fujian Province (2010J06010, 2013J01303), Program for New Century Excellent Talents in Fujian Province University (JA10127), Professor Academic Development Fund of Fujian Medical University (JS12003) and National Natural Science Foundation of China (8107096). Conflicts of interest: none declared. J.C. and M.L. contributed equally to this work. Dear Editor, Primary focal hyperhidrosis (PFH) is a disorder characterized by excessive sweating in specific body areas such as the palm, sole and axillae beyond physiological need, leading to severe psychological, social and occupational dysfunction.1 2 The cause of primary hyperhidrosis still remains unclear. It seems to be associated with neurohumoral or secretory cell metabolic abnormalities, but without structural defects in the sweat glands.3 Much evidence implies that PFH could be a genetic disorder with an autosomal dominant mode of transmission, incomplete penetrance and variable phenotype.4 5 Only one PFH locus has been mapped to chromosome 14q11.2–q13, but no disease‐causing gene has been identified.6
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