Abstract
Spray drying technique was used for 99mTc-labelling of disodium cromoglycate particles. 99mTc was coprecipitated with the drug and nearly spherical radioactive particles were formed with the aerodynamic diameter of 3.8 μm. Labelled particles were inhaled by 7 healthy volunteers using a metering dose aerosol. The deposition of drug particles was monitored by the means of a γ-camera. On average about 9% of the aerosol dose deposited in a whole lung area and about 81% in the mouth, oesophagus and stomach. About 10% of the dose remained in the actuator. The results obtained agree reasonably well with the previously published results of deposition of Teflon particles in the respiratory tract. The novel labelling method used in this study enables evaluation of the deposition of real drug particles in the respiratory tract.
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