A Novel Inflammation-Based Stage (I Stage) in Patients with Resectable Esophageal Squamous Cell Carcinoma.

Peng-Cheng Chen,Ji-Feng Feng

doi:10.1155/2016/5396747

Abstract

Background. Inflammation plays a key role in cancer. In the current study, we proposed a novel inflammation-based stage, named I stage, for patients with resectable esophageal squamous cell carcinoma (ESCC). Methods. Three hundred and twenty-three patients with resectable ESCC were enrolled in the current study. The I stage was calculated as follows: patients with high levels of C-reactive protein (CRP) (>10 mg/L), neutrophil-to-lymphocyte ratio (NLR) (>3.5), and platelet-count-to-lymphocyte ratio (PLR) (>150) were defined as I3. Patients with two, one, or no abnormal value were defined as I2, I1, or I0, respectively. The prognostic factors were evaluated by univariate and multivariate analyses. Results. There were 112 patients for I0, 97 patients for I1, 66 patients for I2, and 48 patients for I3, respectively. The 5-year cancer-specific survival (CSS) in patients with I0, I1, I2, and I3 was 50.0%, 30.9%, 18.2%, and 8.3%, respectively (I0 versus I1, P = 0.002; I1 versus I2, P = 0.012; I2 versus I3, P = 0.020). Multivariate analyses revealed that I stage was an independent prognostic factor in patients with resectable ESCC (P < 0.001). Conclusion. The inflammation-based stage (I stage) is a novel and useful predictive factor for CSS in patients with resectable ESCC.

Highlights

The cancer incidence and mortality have been increasing worldwide
The area under the curve (AUC) was 0.713 for C-reactive protein (CRP), 0.650 for neutrophil-to-lymphocyte ratio (NLR), and 0.685 for platelet-count-to-lymphocyte ratio (PLR)
We initially proposed a novel inflammation-based prognostic system, named inflammation-based stage (I stage), in patients with resectable esophageal squamous cell carcinoma (ESCC)

Summary

Introduction

The cancer incidence and mortality have been increasing worldwide. Esophageal cancer (EC) is one of the most common cancers and remains the 4th leading cause of cancer death [1]. Assessing the prognostic factors in ESCC patients will become more and more important. We proposed a novel inflammation-based stage, named I stage, for patients with resectable esophageal squamous cell carcinoma (ESCC). Three hundred and twenty-three patients with resectable ESCC were enrolled in the current study. The prognostic factors were evaluated by univariate and multivariate analyses. The 5-year cancer-specific survival (CSS) in patients with I0, I1, I2, and I3 was 50.0%, 30.9%, 18.2%, and 8.3%, respectively (I0 versus I1, P = 0.002; I1 versus I2, P = 0.012; I2 versus I3, P = 0.020). Multivariate analyses revealed that I stage was an independent prognostic factor in patients with resectable ESCC (P < 0.001). The inflammation-based stage (I stage) is a novel and useful predictive factor for CSS in patients with resectable ESCC

Methods

Results

Conclusion