Abstract
Hirschsprung’s Disease is characterized by absent ganglia in the distal gastrointestinal tract. Surgical correction may incur significant morbidity. Alternatively, neural progenitor cell transplantation may regenerate the enteric nervous system. Existing aganglionosis model systems are limited by swift animal demise or by spontaneous regeneration of native ganglia. We propose a novel protocol to induce permanent aganglionosis in a segment of rat jejunum, which may serve as an experimental transplantation target for cellular therapy.
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