Abstract
A novel composite drug carrier with excellent sustained and pH-sensitive release performance was prepared by mixing hollow hydroxyapatite (HA) microspheres and chitosan solution with pH-sensitive characteristics. The hollow HA microspheres with mesopores filled on their multilayered spherical shell were obtained by converting borate glass with a novel composition of 19Na2O-17CaO-64B2O3 (wt%). The structure, phase composition and morphology of HA microspheres were characterized by SEM, SEM-EDS, XRD, FTIR and N2 adsorption-desorption measurements. The results indicated that the HA microspheres were B-type carbonated HA with hollow structure, in which the carbonate ions occupied the phosphate sites. The drug release results indicated that the HA microspheres generated burst release at initial stage. Coating the hollow HA microspheres with chitosan (CS) reduced the vancomycin release amount and release rate significantly. Meanwhile, the release profile of vancomycin into PBS with different pH value indicated that the CS-coated composite drug carrier shows pH-sensitive release property. The cumulative percentage of vancomycin released into PBS from the CS (20 g/L)-coated composite drug carrier was 85.63%, 65.85% and 71.85% for pH 6.0, 7.4, 8.5, respectively.
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