Abstract
As a reactive nitrogen species (RNS), peroxynitrite (ONOO−) is known for its crucial functions in biological systems. Excessive formation of ONOO− is very closely related to the pathogenesis of a series of diseases, and thus, effective methods are needed for highly sensitive detection of ONOO−. Herein, a simple fluorescent probe RHHP-PN was proposed to detect ONOO−, and manifested obvious color changes from colorless to red in less than 10 s. Besides, it is not only suitable for quantitative detection of ONOO−, but also satisfactory in distinguishing ONOO− from other related species. What is particularly noteworthy is the fluorescence bioimaging for tracing endogenous and exogenous ONOO− in living cells and zebrafish. Therefore, probe RHHP-PN could be used as an imaging tool to visualize intracellular ONOO− in biological systems.
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