Abstract
A novel and green method is reported to synthesize the stereoisomers of daclatasvir, an antiviral agent. This work mainly explains thesynthesis and characterization of two stereoisomers (S,S,R,S) and (R,S,R,R) of daclatasvir. The slow addition procedure was designed in order to get high yields in the presence of green solvents like DMSO, 2-methyl tetrahydrofuran and isopropyl alcohol. To gain a better understanding of the stability of intermediates, the DFT calculations were also carried out and presented.
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