Abstract
Silver nanoparticles (AgNPs) based antibacterial materials are widely applied to commodity and clinic wound treatments. However, genotoxicity and inflammatory response induced by AgNPs inhibit their application as the antibacterial coating of medical devices like catheters. A novel gelatin-AgNPs coating manufacture method was introduced here to generate an antibacterial coating, which nearly immunes to inflammatory, on basal PHBV material. The novel gelatin-AgNPs coating was produced by immobilizing gelatin on the Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) membrane and subsequently fixing AgNPs on acquired gelatin coating. Prepared gelatin-AgNPs coatings displayed considerable antibacterial capacity. These gelatin-AgNPs coatings did not cause inflammation, growth inhibition or apoptosis to normal human embryonic lung fibroblasts, MRC-5 cells, by analyzing the transcription levels of relevant genes in these cells incubated with tested coatings for 4days. Hence, this novel gelatin-AgNPs coating manufacture method paved its way to apply in medical devices manufacture including catheters.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
