Abstract
Slow disintegration and poor solubility are common problems facing the dispersible tablets of Traditional Chinese Medicine (TCM). In an early study, the research group found that co-grinding of extracts and silica could achieve a rapid disintegration effect, though the mechanism of this effect was not thoroughly elucidated. In this study, Yuanhu Zhitong dispersible tablets (YZDT) were selected as a model drug to explore the mechanism of rapid disintegration and dissolution. First, eight types of silica were used to prepare modified YZDT, and their disintegration time and amount of dissolution within 5 min were measured. Next, the powder properties of eight types of silica were investigated. By correlation analysis, it was found that the average pore size and density of silica were closely related to the effect of promoting disintegration. It was determined that the co-grinding of silica and extracts provided high porosity for the raw material drug, and its abundant narrow channels provided a strong static pressure for water penetration to achieve a rapid disintegration effect. Meanwhile, it was found that the addition of silica had a certain effect on promoting dissolution. Our results provide a highly operational approach for improving the disintegration and dissolution of TCM dispersible tablets. Meanwhile, this approach is also beneficial for establishing a high-quality evaluation index for silica.
Highlights
Small[11,12], while the physical properties of Chinese herbal extracts are complex, and the dosages reach 30–40%13
It will be beneficial to form a new pattern for the preparation of Traditional Chinese Medicine (TCM) dispersible tablets, which is of great interest to pharmacists
These results showed that almost all of the five components dissolved relatively faster from A 200 modified Yuanhu Zhitong dispersible tablets (YZDT), while the precipitated silica (PS) was slower
Summary
Small[11,12], while the physical properties of Chinese herbal extracts are complex, and the dosages reach 30–40%13. Because researchers have ignored the complex physical and chemical properties of Chinese herbal extracts, a series of technical problems have been encountered, such as disintegration retardation, loose quality, and tablet splitting. Whether the rapid disintegration of dispersible tablets would promote the immediate release of ingredients needed to be explored In this manuscript, a famous Chinese patent medicine with analgesic effect, YZDT, was selected as a model drug. Correlation analysis was used to explore the main powder properties affecting the disintegration effect On this basis, we further studied the release ability of five active components in YZDT after silica modification (Fig. 1). It will be beneficial to form a new pattern for the preparation of TCM dispersible tablets, which is of great interest to pharmacists
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