Abstract
3,4-Disubstituted isothiazoles (8a, b, 9a, b, 10, 11, 14a,b) were synthesized from 5-amino-6-methyl-4(3 H)-pynmidinone (1) or 1,3-disubstituted 5-amino-6-methyluracils (12a,b) via the formation of isothiazolo[4,3- d] pyrimidines (6, 13a, b) followed by the reaction with alkylamines.
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