Abstract
This study developed an innovative foamy collagen dural substitute. The foamy collagen was prepared by mixing collagen hydrogel and high-pressure oxygen in a stainless steel bottle as a container. A foamy collagen with 101 ± 43 μm in pore size and 50.5 ± 5.1% in porosity formed after release from the container. In the results of the in vitro degradation experiment, foamy collagen degraded slower than the commercially available DuraGen treated with 5 units/mL of collagenase solution. DuraGen degraded completely within three hours and foamy collagen had 39.2% (mean) of its original mass remaining 24 h after immersing in collagenase solution. The oxygen bubble structure was immobilized by the collagen fibrillogenesis and remained intact 3 and 7 days after subcutaneous implantation of the foamy collagen in rats, without any escape or merge of the oxygen bubbles. Fibrous tissue proliferated along the porous structure from the edge of the foamy collagen according to the histology analysis of subcutaneous implantation experiment in rats. The results of in vivo rabbit duraplasty experiment showed that the regenerated dura in foamy collagen group was thicker than that in DuraGen group, and was comparable to the native dura mater, without causing any adverse effects, such as intracranial pressure increase or cerebrospinal fluid leakage.
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