A Novel Fluoride Containing Bioactive Glass Paste is Capable of Re-Mineralizing Early Caries Lesions.

Ahmed Bakry,Mona Abbassy,Khalil Al-Ghamdi,Sara Basuhail,Hanin Alharkan,Robert Hill

doi:10.3390/ma11091636

Abstract

White-spot-lesions (WSL) are a common complication associated with orthodontic treatment. In the current study, the remineralization efficacy of a BiominF® paste was compared to the efficacy of a fluoride gel. Methods: Orthodontic brackets were bonded to 60 human premolars buccal surfaces, which were covered with varnish, except a small treatment area (3 mm2). All specimens were challenged by a demineralization solution for 4 days. Specimens were assigned into 4 groups: BiominF® paste, Fluoride (4-min application), fluoride (twenty four hours application), and the control (n = 15). After cross-sectioning, enamel slabs having a thickness of approximately 100–120 μm were obtained. A TMR (Transverse Micro Radiography) technique was used to observe the sub-surface enamel lesions’ depth and mineral density, and their response to the remineralization protocols. One way ANOVA was used to analyze the results (α = 0.05). The top and the cross-sectional surfaces were observed using SEM/EDS. Results: Specimens treated with BiominF® paste showed significant decrease in delta z values, however lesion depth showed no significant difference when compared to the other three groups (p < 0.05). SEM/EDS observation showed the formation of crystal like structures on top of enamel demineralized surfaces, when treated with BiominF® paste. In conclusion BiominF® paste can be considered an effective remineralizing agent for white spot Lesions.

Highlights

Many orthodontic patients seek improvement in their dental aesthetic features; orthodontic treatment is often associated with the development of white spot lesions, which is extremely difficult to treat [1]
The increase in caries risk factors in orthodontic patients may be attributed to the presence of many retentive areas surrounding the enamel brackets, which retain large quantities of cariogenic oral biofilm [2]
Previous studies showed that the levels of cariogenic biofilm in the oral cavities of orthodontic patients, may be 2–3 times higher than in normal individuals suffering from high rates of biofilm formation [3]

Summary

Introduction

Many orthodontic patients seek improvement in their dental aesthetic features; orthodontic treatment is often associated with the development of white spot lesions, which is extremely difficult to treat [1]. Progress of these lesions to form cavities occurs frequently in many cases, jeopardizing the final expected esthetic results [1]. Previous studies showed that the levels of cariogenic biofilm in the oral cavities of orthodontic patients, may be 2–3 times higher than in normal individuals suffering from high rates of biofilm formation [3]. The spread of dietary habits and assorted systemic [4,5,6] and genetic disorders [7], may lead to the development various earlyand enamel lesions, which [4,5,6]

Methods

Results

Discussion

Conclusion