Abstract
We have constructed a pyrene-labeled guanine base, 8PyG. 8PyG is a novel fluorescent probe for monitoring the secondary structure of G-rich DNA. The fluorescence emitted from 8PyG-labeled oligodeoxynucleotide clearly distinguished three structural states, single strand–duplex–quadruplex. Thus, the technique, which monitors the fluorescence of 8PyG-labeled oligodeoxynucleotide, is a powerful tool for the investigation of DNA structural changes.
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