A Novel Extraction-Cleanup Method for Determination of Trace PPCPs in Water Samples

Abstract

In this contribution, a simple and sensitive extraction-cleanup method which was termed MAE-μ-SPE, was developed for the analysis of pharmaceutical and personal care products (PPCPs) in environmental water samples. The PPCPs included bisphenol A (BPA), diethyl phthalate (DEP), dibutyl phthalate (DBP), di (2-ethylhexyl) phthalate (DEHP), tetracycline (TC), deoxytetracycline (DC), oxytetracycline (OTC) and chloroteracycline (CTC). In this method, the PPCPs in the samples were extracted by microwave-assisted extraction (MAE) following adsorbed by copper (II) isonicotinate in micro-solid phase extraction (μ-SPE) device. The PPCPs were determined by high performance liquid chromatography with ultra-violet detector (HPLC-UV). The procedure of the MAE-μ-SPE was optimized in extraction temperature, extraction time, desorption time and desorption solvent. Analytical performances, such as limits of detection (in the range of 2.0-8.5 μg/L), quantification (in the range of 6.6-28.0 μg/L), and repeatability of the over-all procedure (less than 13%) were established. DEP, DBP, DEHP and TC studied in water samples were ranged from 18.2-68.8 μg L-1, while BPA, OTC, CTC and DC were found all below the detection limit in these samples.