Abstract
The chromatographic separation of aqueous methanolic extract ofCalendula officinalisled to the isolation of a new eudesmane sesquiterpene glycoside (1), together with tow known compounds, a lupane ester (2) and flavonoide gulcoside (3). Their structures were characterized to be 1β,3β,6α,8α,tetrahydroxyeudesm-4-ene 11-O-β-D-glucopyrnoside (1), 3β-E-caffoeyl lupeol (2), kaempferol-3-O-gulcoside (3) by spectroscopic means.
Highlights
The genus Calendula belongs to the Asteraceae family and encloses more than 20 species distribution around the world
Compound (1) gave a molecular ion peak in its EI-MS spectrum at m/z 448, in agreement with the molecular formula C21H36O10, The other prominent peaks were found to occur at m/z 430 [M-H2O]+, 412 [M-2H2O]+, 269 [M-glucose]+, 227, 209
The 13C-NMR spectra of (1) showed signals for four methyl carbons (δ 16.80, 18.20, 27.77 and 31.84), ascribed to C-14, C-15, C-12 and C-13 respectively, three methylene carbons, a ten methine carbons, five of it ascribed to eudesmane skeleton and five to sugar moiety
Summary
The genus Calendula belongs to the Asteraceae family and encloses more than 20 species distribution around the world. This plant is used in folk medicine for the treatment of digestive disorders, inflammation, emmenagogue, and as tonic, stimulant and antibacterial remedies. Previous studies demonstrated therapeutic potentialities of Calendula officinalis L. such as anti-inflammatory activity [2,3,4,5], immunomodulatory [6,7], Hepatoprotective [8], wound-healing [9], antioxidant [10,11,12], antibacterial and antiparasitic activity [13,14,15,16]. The essential oil from C. officinalis has been investigated [17,18,19,20,21,22]
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