Abstract
Enzootic nasal tumor virus (ENTV) has two types, ENTV-1 in sheep and ENTV-2 in goats, respectively. In China, the incidence of ENTV-2 related diseases has increased year by year. In this study, we reported an outbreak of ENTV-2 in a commercial goat farm in Qingyuan city, Guangdong province, southern China. A full-length genome of ENTV-2 (designated GDQY2017), with 7479 base pairs, was sequenced. Although GDQY2017 shared the highest nucleotide identity with a Chinese ENTV-2 isolate (ENTV-2CHN4, GenBank accession number KU258873), it possesses distinct genome characteristics undescribed, including a non-continuous 21-nucleotide insertion in the gag gene and a non-continuous 12-nucleotide deletion in the env gene. Notably, most of these indel nucleotide sequences were originated from a Chinese jaagsiekte sheep retrovirus (JSRV) isolate (GenBank accession number DQ838494). In the gag and env genes, GDQY2017 was phylogenetically related to those Chinese ENTV-2 isolates and a Chinese JSRV isolate (DQ838494). For GDQY2017-like viruses, more surveillance work should be made to explain their pathogenicity in goat herds. To our knowledge, this study represents the first to demonstrate the circulating pattern of ENTV-2 in Guangdong province, China, which will help to better understand the epidemiology and genetic diversity of ENTV-2.
Highlights
Enzootic nasal tumor virus (ENTV) is a single positive-stranded RNA virus that belongs to the genus Betaretrovirus in the family Retroviridae
ENTV is is close close to to jaagsiekte retrovirus (JSRV, another ovine betaretrovirus), which is the causative agent of ovine pulmonary retrovirus (JSRV, another ovine betaretrovirus), which is the causative agent of ovine pulmonary adenocarcinoma (OPA)
2), the 2), tumor in the goat considered to be nasalwhich adenoma, which was in compliance withof the feature of enzootic nasalnasal adenocarcinoma (ENA)
Summary
Shao-Lun Zhai 1 , Dian-Hong Lv 1 , Zhi-Hong Xu 1 , Jie-Shi Yu 2 , Xiao-Hui Wen 1 , He Zhang 1 , Qin-Ling Chen 1 , Chun-Ling Jia 1 , Xiu-Rong Zhou 1 , Qi Zhai 1 , Feng Li 2 , Patrick C. P. Lau 3,4,5, *, Dan Wang 2, * and Wen-Kang Wei 1, *. Animal Disease Diagnostic Center, Institute of Animal Health, Guangdong Academy of Agricultural. Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Key Laboratory of Animal Disease. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong. Received: 5 September 2019; Accepted: 14 October 2019; Published: 17 October 2019
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