Abstract
Cryoablation has been used for the treatment of various sorts of solid visceral tumors, but few are reported on gastric tumor via endoscope, in terms of accurate control of ablation site, freezing depth and effective temperature. Thus, we developed a novel device, which could perform accurate cryoablation on the stomach via endoscope. This study aimed to evaluate the efficacy and safety of the device on porcine stomach. Results showed that the novel device could provide direct view of the operation space, allowing accurate and safe ablation of the stomach. Three minutes cryoablation caused a transmural, 1 cm radius gastric lesion. On serosal side, the temperature dropped to −64.2 °C, −34.1 °C, 26.1 °C at the center, 1 cm and 2 cm from center, respectively. Histopathology revealed acute ruptured cells with damaged glands in mucosa, partial disruption in muscularis propria and serosal slight exudation. Three months later, scar formed with complete recovery of gastric structure. No active bleeding or perforation of stomach, nor injury or adhesion of adjacent organs was observed. This endoscopic cryoablation device allowed safe, full-thickness cryoablation with effective temperature, which may provide an alternative treatment for gastric tumor.
Highlights
Cryoablation has been used for the treatment of various sorts of solid visceral tumors, but few are reported on gastric tumor via endoscope, in terms of accurate control of ablation site, freezing depth and effective temperature
Few cases report the use of endoscopic cryoablation on the treatment of gastric tumors, since this required more specialized equipment
Current reported endoscopic cryoablation devices are mainly spraying device, which are only appropriate for the treatment of mucosal lesion, such as Barrett’s esophagus[2,3,4]
Summary
Cryoablation has been used for the treatment of various sorts of solid visceral tumors, but few are reported on gastric tumor via endoscope, in terms of accurate control of ablation site, freezing depth and effective temperature. No active bleeding or perforation of stomach, nor injury or adhesion of adjacent organs was observed This endoscopic cryoablation device allowed safe, full-thickness cryoablation with effective temperature, which may provide an alternative treatment for gastric tumor. Current reported endoscopic cryoablation devices are mainly spraying device, which are only appropriate for the treatment of mucosal lesion, such as Barrett’s esophagus[2,3,4] These spraying devices, which are operated by spraying compressed carbon dioxide, can’t only cause transmural injury[3]. Due to the large cavity and peristalsis of the stomach, it is difficult to control the volume of the balloon, the cryoablation could hardly be achieved on the stomach These reported endoscopic cryoablation devices do not apply to the treatment of gastric tumor, because they could not implement accurate cryoablation and efficient injury infiltration depth. An animal experiment was designed to evaluate the efficacy and safety of the device
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
