Abstract
A conceptually simple enantioselective 14-step synthesis of (+)-biotin from L-cysteine is reported based upon an intramolecular 1,3-dipolar cycloaddition sequence involving (i) elimination of bromide 8 to the endocyclic thioenol ether 9, (ii) thermolysis of the ene carbamoyl azide 9 to the exocyclic thioenol ether 10. Both the synthesis of 8 and the final transformation of 10 into (+)-biotin are based upon literature precedents.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have