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Abstract
Ethyl pyruvate (EP), as a pyruvate derivative, has the protective effect on oxidative-stress-mediated cellular injury. In previous studies, it has been reported that EP provides protection against neuronal injury in brain, for example transient cerebral ischemia. However, the inhibition effect of EP on peripheral nerve injury is still unknown. Here, we investigated the inhibition effect of EP in Schwann cell de-differentiation and proliferation during Wallerian degeneration using ex vivo sciatic nerve explant system. We demonstrated that EP inhibits p-ERK1/2, p75NGFR, and lysosomal associated membrane protein 1 as factors implicated in Schwann cell de-differentiation during Wallerian degeneration. In addition, EP is sufficient to inhibit Schwann cell proliferation during Wallerian degeneration. Together, these findings suggest that EP has a strong protective effect on Wallerain degeneration.
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