Abstract
Recently, chitosan (CS) was given much attention as a functional biopolymer for designing various hydrogels for industrial, environmental and biomedical applications, but their biomedical use is limited due to the toxicity of the crosslinker agents. To overcome this inconvenience, we developed an auto cross-linked material based on a chitosan backbone that carries an amino and aldehyde moieties. This new drug delivery system (DDS) was designed by using oxidized chitosan (OCS) that crosslinks chitosan (CS). In the first part, a simple, rapid, low-cost and eco-friendly green method was introduced to synthesize magnetite nanoparticles (Fe3O4-NPs) successfully. These nanoparticles Fe3O4 have received a great deal of attention in the biomedical field. Especially in a targeted drug delivery system, drug-loaded Fe3O4-NPs can accumulate at the tumor site by the aid of an external magnetic field and increase the effectiveness of drug release to the tumor site. In the second part, we have incorporated the Fe3O4-NPs into chitosan/oxidized chitosan solution because of their unique magnetic properties, outstanding magnetism, biocompatibility, lower toxicity, biodegradability, and other features. Three drugs (5-Fluorouracil (5-FU), Caffeine and Ascorbic acid)) were embedded into the magnetite solution that became quickly a hydrogel. The successful fabrication of the hydrogels and ferrogels was confirmed by (FT-IR), (TGA), (SEM), (VSM) analysis at room temperature. Finally, results showed that our hydrogels and ferrogels may be technologically used as devices for drug delivery in a controllable manner.
Highlights
Nowadays, the global increase in the number of people with chronic diseases as “cancer, diabetes, etc.” have affected the health and quality of life of many citizens around the world
The hydrogels and ferrogels were prepared by crosslinking chitosan (CS) with oxidized chitosan (OCS)
Our results indicate that the process synthesis of the hydrogel and ferrogel was embedded with three drugs (5-FU, caffeine and ascorbic acid) has successfully loaded in the carrier polymeric
Summary
The global increase in the number of people with chronic diseases as “cancer, diabetes, etc.” have affected the health and quality of life of many citizens around the world. Cancer is considered a public health problem because of its high incidence and mortality. Chitin and Chitosan - Physicochemical Properties and Industrial Applications estimates 27 million cases of cancer and 17 million deaths disease for the year 2030 [1]. Cancer chemotherapy is widely used despite its disadvantages. Chemotherapy usually causes serious side effects because of the low selectivity of anti-cancer drugs, which affects cancer cells and normal cells [2]. Increasing attention is being paid to targeted drug delivery systems, which have been used to increase the efficiency of drug delivery to specific tissues and to decrease the associated side effects
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