Abstract
Background: Growing evidence has confirmed that populations with type 2 diabetes mellitus (T2DM) have an increasing risk of developing colorectal cancer (CRC). Thus, convenient and effective screening strategies for CRC should be developed for the T2DM population to increase the detection rate of CRC. Methods: Twenty serum samples extracted from five healthy participants, five T2DM patients, five CRC patients and five T2DM patients with CRC (T2DM + CRC) were submitted to data-independent acquisition mass spectrometry (DIA-MS) analysis to discover unique differentially altered proteins (DAPs) for CRC in patients with T2DM. Then, the diagnostic value of pregnancy zone protein (PZP) was validated by ELISA analysis in the validated cohort. Results: Based on DIA-MS analysis, we found eight unique proteins specific to T2DM patients with CRC. Among these proteins, four proteins showed different expression between the T2DM + CRC and T2DM groups, and PZP exhibited the largest difference. Next, the diagnostic value of serum PZP was validated by ELISA analysis with an AUC of 0.713. Moreover, the combination of PZP, CA199 and CEA exhibited encouraging diagnostic value, and the AUC reached 0.916. Conclusion: Overall, our current research implied that PZP could be regarded as a newfound serum biomarker for CRC medical diagnosis in T2DM patients.
Highlights
Diabetes mellitus is a widespread chronic disease, especially type 2 diabetes mellitus (T2DM), whose incidence is increasing gradually
The T2DM population should be regarded as a high-risk population prone to Colorectal cancer (CRC), and convenient and effective screening strategies for CRC should be developed for the T2DM population to increase the detection rate of CRC and improve the prognosis of these patients
The general clinicopathological characteristics in the two groups in the validation cohort consisting of 40 T2DM patients and 32 T2DM + CRC patients were compared
Summary
Diabetes mellitus is a widespread chronic disease, especially type 2 diabetes mellitus (T2DM), whose incidence is increasing gradually. Increasing evidence has confirmed that T2DM patients face an enhanced threat of suffering from CRC compared to a population without the disease (Larsson et al, 2005; Elwing et al, 2006; Yu et al, 2016). The T2DM population should be regarded as a high-risk population prone to CRC, and convenient and effective screening strategies for CRC should be developed for the T2DM population to increase the detection rate of CRC and improve the prognosis of these patients. Growing evidence has confirmed that populations with type 2 diabetes mellitus (T2DM) have an increasing risk of developing colorectal cancer (CRC). Convenient and effective screening strategies for CRC should be developed for the T2DM population to increase the detection rate of CRC
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