Abstract
Despite being the most common endocrinological disorder of reproductive aged women, polycystic ovary syndrome (PCOS) remains a complex disease of unknown etiology. Patients spend an average of two years of clinical evaluation with at least three health professionals before diagnosis. As PCOS remains a diagnosis of exclusion, there is room for improvement in diagnostic classification. Although the use of Antimullerian hormone (AMH) as a diagnostic test has shown promise, it has limitations. Our laboratory has identifiedvariation in levels of activating autoantibody (AAb) to the second extracellular loop of the gonadotropin-releasing hormone receptor (GnRHR) associated with PCOS in infertile patients.
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