A novel deep recurrent convolutional neural network for subthalamic nucleus localization using local field potential signals

Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established interventional treatment for improving motor symptoms of patients suffering from Parkinson’s disease (PD). While STN is originally localized using imaging modalities, additional intraoperative guidance such as microelectrode recording (MER) is crucial to refine the final electrode trajectory. Analysis of MER by an experienced neurophysiologist maintains good clinical outcomes, although the procedure requires long duration and jeopardizes the safety of the surgery. Lately, local field potentials (LFP) investigation has inspired the emergence of adaptive DBS and revealed beneficial perception of PD mechanisms. Several studies confronting LFP analysis to detect the anatomical borders of STN, have focused on handcrafted feature engineering, which does not certainly capture delicate differences in LFP. This study gauges the ability of deep learning to exhibit valuable insight into the electrophysiological neural rhythms of STN using LFP. A recurrent convolutional neural network (CNN) strategy is presented, where local features are extracted from LFP signals via CNN, followed by recurrent layers to aggregate the best features for classification. The proposed model outperformed the state-of-the-art techniques, yielding highest average accuracy of 96.79%. This is the first study on the analysis of LFP signals to localize STN using deep recurrent CNN. The developed model has the potential to extract high level biomarkers regarding STN region, which would boost the neurosurgeon’s confidence in adjusting the trajectory intraoperatively for optimal lead implantation. LFP is a robust guidance tool and could be an alternative solution to the current scenario using MER.