In image-based diagnosis, machine learning recently showed great potential, particularly in the detection of cancer, the identification of tumour cells, and the diagnosis of COVID-19. Similar methods could be used to detect monkeypox on human skin, however there isn’t a public dataset with data on monkeypox that can be used to train and evaluate machine learning models. In order to address this, the dataset “Monkeypox2022” has been created and made available on GitHub (https://github.com/Angmo21720/data-set). Images from internet and open-source sources were used to construct the collection; these sources did not impose any restrictions on use, including commercial use. Additionally, the enhanced VGG16 model was proposed and ran two Studies for comparison. According to the findings, the model’s AUC Score for identifying monkeypox patients in Study One was 0.972, while its AUC Score for identifying such patients in Study Two was 0.748. Deeper understanding of the characteristics that distinguish a monkeypox infection is provided by using Local Interpretable Model-Agnostic Explanations (LIME), which is used to decipher predictions and reveal the features utilized by a model in decision-making.

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