A novel curcumin derivative, f-methyl-curcumin-1 (fmec1), is a potential diagnostic and therapeutic agent for Alzheimer's disease.

Abstract

Event Abstract Back to Event A novel curcumin derivative, f-methyl-curcumin-1 (fmec1), is a potential diagnostic and therapeutic agent for Alzheimer's disease. Ikuo Tooyama1*, Daijiro Yanagisawa1 and Nor Faeizah Ibrahim1 1 Shiga University of Medical Science, Molecular Neuroscience Research Center, Japan Curcumin has various beneficial pharmacological properties such as anti-tumor, anti-oxidative, and anti-inflammatory effects. Also, some recent reports of in vitro and in vivo experiments suggest favorable effects of curcumin in preventing or treating Alzheimer’s disease (AD) pathology. However, the first clinical trial of curcumin on patients with AD showed no effects. Therefore, more effective curcumin analogues may be needed. We recently developed a novel curcumin derivative, 1,7-Bis(4’-hydroxy-3’-trifluoromethoxyphenyl)-4-methoxycarbonylethyl-1,6-heptadiene-3,5-dione (FMeC1) as a fluorine-19 MRI probe to detect amyloid deposition. We present here the effects of our new compounds on Aβ aggregation in vitro and AD pathology in a mouse model of AD. APPswe/PS1dE9 double transgenic mice were fed with a standard lab chow diet with or without curcumin, FMeC1, or FMeC2 (500 ppm which is equivalent to ~1.25 mg/day or 83 mg/kg body weight) for 6 months from 9 months of age. FMeC1-treated mice showed a reduction in insoluble Aβ deposits and glial activation together with reduced cognitive deficits, compared to animals receiving a control diet or with curcumin or FMeC2 in their diet. Quartz crystal microbalance analysis showed that curcumin and FMeC1 bound not only to Aβ aggregates but also to Aβ oligomers, which are responsible for neuronal and synaptic dysfunction in AD. Both curcumin and FMeC1 modulated the formation of Aβ aggregates, but only FMeC1 significantly attenuated the cell toxicity of Aβ. Keywords: Curcumin, Oxidative Stress, Alzheimer, neurodegeneration, antioxidant Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Symposium 7: New Insights on Oxidative Stress in Neurodegenerative Diseases and Therapeutic Potential of Anti- Oxidants as a Drug for the Pre-Emptive Medicine Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Tooyama I, Yanagisawa D and Ibrahim N (2016). A novel curcumin derivative, f-methyl-curcumin-1 (fmec1), is a potential diagnostic and therapeutic agent for Alzheimer's disease.. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00031 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Jul 2016; Published Online: 11 Aug 2016. * Correspondence: Prof. Ikuo Tooyama, Shiga University of Medical Science, Molecular Neuroscience Research Center, Otsu, Shiga, Japan, kinchan@belle.shiga-med.ac.jp Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ikuo Tooyama Daijiro Yanagisawa Nor Faeizah Ibrahim Google Ikuo Tooyama Daijiro Yanagisawa Nor Faeizah Ibrahim Google Scholar Ikuo Tooyama Daijiro Yanagisawa Nor Faeizah Ibrahim PubMed Ikuo Tooyama Daijiro Yanagisawa Nor Faeizah Ibrahim Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.