Abstract
The dry powder inhaler is a new form of drug delivery that is widely used as an alternative to traditional drug delivery methods, addressing the shortcomings of traditional drug delivery methods and obtaining better therapeutic results. This mode of delivery is also one of the most rational ways to treat pulmonary diseases such as chronic obstructive pulmonary disease (COPD). Curcumin, a natural polyphenol, has been shown to be effective in the treatment of COPD. In this study, different concentrations of curcumin ethanol solution were spray dried with mannitol as a carrier to obtain dry powder particles with different particle size distribution for the preparation of curcumin dry powder inhaler. The solubility and physicochemical properties were further characterized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscopy. The characterization results showed that the product obtained in the experiment had reasonable particle size distribution and excellent solubility properties, which were positive for the treatment of COPD or other pulmonary diseases.
Highlights
Chronic obstructive pulmonary disease (COPD) is a not fully reversible chronic respiratory disease that progresses slowly and is characterized by obstructive ventilation patterns, often associated with smoke, air pollution, radiation, and viral infections, and can lead to severe chronic respiratory failure [1, 2]
Curcumin downregulates protein 66 homolog-collagen homolog (p66Shc), promotes the expression of RNA encoding SIRT1 histone deoxygenase, promotes protein autophagy, and inhibits ERS, thereby reducing alveolar epithelial damage in COPD; on the other hand, it inhibits BEAS-2B cell proliferation and suppresses NF-κB and COX-2 expression, thereby reducing airway inflammation and airway remodelling. It alleviates COPD symptoms in several ways and has a positive therapeutic effect. ese studies imply that curcumin has great potential for clinical application in the treatment of pulmonary diseases, especially for COPD [21, 22]
Our study proposes the application of spray drying technology to improve water solubility for the preparation of dry powder inhalers for pulmonary inhalation
Summary
Chronic obstructive pulmonary disease (COPD) is a not fully reversible chronic respiratory disease that progresses slowly and is characterized by obstructive ventilation patterns, often associated with smoke, air pollution, radiation, and viral infections, and can lead to severe chronic respiratory failure [1, 2]. Curcumin downregulates protein 66 homolog-collagen homolog (p66Shc), promotes the expression of RNA encoding SIRT1 histone deoxygenase, promotes protein autophagy, and inhibits ERS (endoplasmic reticulum stress), thereby reducing alveolar epithelial damage in COPD; on the other hand, it inhibits BEAS-2B cell proliferation and suppresses NF-κB and COX-2 expression, thereby reducing airway inflammation and airway remodelling. It alleviates COPD symptoms in several ways and has a positive therapeutic effect. It alleviates COPD symptoms in several ways and has a positive therapeutic effect. ese studies imply that curcumin has great potential for clinical application in the treatment of pulmonary diseases, especially for COPD [21, 22]
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