Abstract
Although cyanogen ion (CN-) plays important role in industry which also bring acute environmental pollution. More serious, trace CN- enters the human body can cause serious consequences and even death. Therefore, it is of great significance to detect trace CN- with high sensitivity. Herein, a novel aggregation-induced emission (AIE) probe C-BH was synthesized based on coumarin matrix. Probe C-BH showed high selectivity and sensitivity toward CN- by dual channel response due to the excited state intramolecular proton transfer (ESIPT). The low detection limit was calculated to be 0.05µM. Moreover, probe C-BH was successfully used for imaging CN- in living cells and zebrafish due to its low toxicity and excellent optical properties.
Highlights
IntroductionTrace CN− can cause serious damage to the central nervous system by combining with Fe3+ of heme unit in hemoglobin [2]
Cyanogen ion (CN−) is notorious for its strong toxicity [1]
Coumarin was selected as fluorescent parent, benzophenone hydrazone was introduced by Schiff base reaction for giving probe C-BH with high yields
Summary
Trace CN− can cause serious damage to the central nervous system by combining with Fe3+ of heme unit in hemoglobin [2]. Accurate detection of CN− concentration in living organisms is of great significance to maintain the vitality of living organisms. Made some progress [6,7,8,9,10] Some defects such as high expenses, time-consuming and complicated operations made these measurement not easy to promote. It is urgent for developing new detection methods to overcome these defects and realize simple, rapid and high sensitivity detection of trace CN−
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