Abstract
AbstractThe multicomponent domino Knoevenagel hetero‐DielsAlder hydrogenation process of N‐[(benzyloxy)carbonyl(Cbz)‐protected amino aldehydes with N,N‐dimethylbarbituric acid and the trimethylsilyl enol ethers 1–3 leads to the formation of the substituted pyrrolidines 12–15. Under the same conditions, reaction of the trimethylsilyl enol ether 4, obtained from acetophenone, gave the primary amines 18a,b probably due to a hydrogenolytic cleavage of the intermediately formed pyrrolidines. The zwitterionic products were obtained in high purity simply by precipitation with Et2O.
Published Version
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