Abstract
Background and Aims : Preclinical mouse models are lacked in predicting the pathomechanisms of cardiometabolic diseases and explore new therapeutic agents. Using double-knockouts in ApoE−/− or LDLR−/− background mice are impractical due to the extensive amount of breeding required and substantial costly. Recently reports indicated that overexpression of PCSK9 (AAV8-PCSK9) can induced spontaneous hyperlipidemia which mediated by adeno-associated-virus-8 (AAV8). The purpose of our research was to assess the injection of AAV-PCSK9 vectors in db/db mice as a novel compound mouse model of diabetes, atherosclerosis and fatty liver to study the cardiometabolic diseases and complications.
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