Abstract
We recently described a new component (TAC102) of the mitochondrial genome segregation machinery (mtGSM) in the protozoan parasite Trypanosoma brucei. T. brucei belongs to a group of organisms that contain a single mitochondrial organelle with a single mitochondrial genome (mt-genome) per cell. The mt-genome consists of 5000 minicircles (1 kb) and 25 maxicircles (23 kb) that are catenated into a large network. After replication of the network its segregation is driven by the separating basal bodies, which are homologous structures to the centrioles organizing the spindle apparatus in many eukaryotes. The structure connecting the basal body to the mt-genome was named the Tripartite Attachment Complex (TAC) owing its name to the distribution across three areas in the cell including the two mitochondrial membranes.
Highlights
Proper segregation of the mt-genome during cell division is a general problem in biology and until now only a few components have been identified
We recently described a new component (TAC102) of the mitochondrial genome segregation machinery in the protozoan parasite Trypanosoma brucei
T. brucei belongs to a group of organisms that contain a single mitochondrial organelle with a single mitochondrial genome per cell
Summary
Proper segregation of the mt-genome during cell division is a general problem in biology and until now only a few components have been identified.
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