Abstract
A series of novel arylpiperidines ( 4a-d) which have highly potent blocking effects for both neuronal Na + and T-type Ca 2+ channels with extremely low affinity for dopamine D 2 receptors were synthesized. Among these compounds, 1-(2-hydroxy-3-phenoxy)propyl-4-(4-phenoxyphenyl)-piperidine hydrochloride ( 4c; SUN N5030) exhibited remarkable neuroprotective activity in a transient middle cerebral artery occlusion (MCAO) model.
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