Abstract
The synthesis and initial SAR studies of novel, highly potent positive allosteric modulators of AMPA receptors based on 3-(4- tert-butylphenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid ( 6a) are described. SAR studies at the thioether moiety indicated that substitution at this position was mandatory and better potency was achieved with small groups.
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