Abstract
Abstract A novel chiral stationary phase, [(1R,2S)-2-hydroxy-1-methyl-2-phenylethylamino]acetic acid, was prepared from (−)-norephedrine, and its sodium salt was bound to silica gel pretreated with [3-(glycidyloxy)propyl]trimethoxysilane. The chiral stationary phase was found to be effective for the optical resolution of amino acids and their derivatives by ligand-exchange high-performance liquid chromatography using aq copper(II) sulfate solution as an eluent.
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