A novel BODIPY-based theranostic agent for in vivo fluorescence imaging of cerebral Aβ and ameliorating Aβ-associated disorders in Alzheimer's disease transgenic mice

Abstract

We report the synthesis, characteristics, and biological evaluations of a novel theranostic agent, P14, for both in vitro and in vivo imaging of central Aβ plaques, inhibition of Aβ aggregation, and neuronal damage as well as behavioral deficits.