A novel binuclear Lanthanum complex containing 1,10-phenanthroline; from crystal structure to biological and antitumor activity

Abstract

UV–Vis and IR spectroscopy, elemental analysis, and X-ray crystallography are used to characterize a novel dimeric Lanthanum(III) complex with 1,10-phenanthroline (phen), [LaCl2(Phen)2-µ-Cl2- LaCl2(Phen)2]. It is also being examined for its antibacterial, anticancer, and DNA (Fish Salmon DNA) and protein (Bovine Serum Albumin) binding properties. The title compound's crystals are triclinic, P1¯; with a (Å) = 9.914(3), b (Å) = 10.927(3), c (Å) = 12.047(3), V (Å3) = 1151.7(5), α (°) = 84.797(5), β (°) = 77.224(4), γ (°) = 64.814(5), Z = 1 and Dcalc = 1.747 (g/cm3). It has a centrosymmetric binuclear [LaCl2(Phen)2 (µ-Cl)]2 unit (the two bridging chlorine atoms lie on an inversion center). The molecular modeling method was used to study the binding qualities both empirically and conceptually. Absorption and fluorescence spectroscopy methods were used to determine thermodynamic parameters, the binding constant (Kb), and the possible binding process. With a binding constant (Kb) of 1.78 × 105, the volume of binding to FS DNA supports groove binding, which is consistent with docking estimates. With a static technique, the as-synthesized complex efficiently suppressed BSA emission and was bound by Kb = 1.17 × 105 at 298 K, demonstrating its high tendency for BSA contact via van der Waals force and hydrogen bond. Antimicrobial testing on a variety of bacteria revealed that it has good antibacterial action. The MTT method was used to test the in vitro cytotoxicity of the La2(III) complex in A-549 cell lines, which exhibited considerable activity.