Abstract
Objective: Microwave technology, together with enzymatic catalysis, is a nature-friendly chemical synthesis method with low wastage of solvent and a good yield of the products. Methods: Enzymes from various microorganisms can be used in the biochemical processes of a wide range of compounds assisted by microwave irradiation. Results: In this work, the microwave-induced reaction of α-keto β-lactams by Baker's yeast in organic solvent was conducted to afford optically active cis and trans-α-hydroxy-β-lactams for the first time. Conclusion: These hydroxy compounds are the precursors of numerous natural products of medicinal significance.
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