Abstract
Long non‐coding RNAs (lncRNAs) are well known as crucial regulators to breast cancer development and are implicated in controlling autophagy. LncRNAs are also emerging as valuable prognostic factors for breast cancer patients. It is critical to identify autophagy‐related lncRNAs with prognostic value in breast cancer. In this study, we identified autophagy‐related lncRNAs in breast cancer by constructing a co‐expression network of autophagy‐related mRNAs‐lncRNAs from The Cancer Genome Atlas (TCGA). We evaluated the prognostic value of these autophagy‐related lncRNAs by univariate and multivariate Cox proportional hazards analyses and eventually obtained a prognostic risk model consisting of 11 autophagy‐related lncRNAs (U62317.4, LINC01016, LINC02166, C6orf99, LINC00992, BAIAP2‐DT, AC245297.3, AC090912.1, Z68871.1, LINC00578 and LINC01871). The risk model was further validated as a novel independent prognostic factor for breast cancer patients based on the calculated risk score by Kaplan‐Meier analysis, univariate and multivariate Cox regression analyses and time‐dependent receiver operating characteristic (ROC) curve analysis. Moreover, based on the risk model, the low‐risk and high‐risk groups displayed different autophagy and oncogenic statues by principal component analysis (PCA) and Gene Set Enrichment Analysis (GSEA) functional annotation. Taken together, these findings suggested that the risk model of the 11 autophagy‐related lncRNAs has significant prognostic value for breast cancer and might be autophagy‐related therapeutic targets in clinical practice.
Highlights
Breast cancer is the most frequent malignancy and the leading cause of cancer-associated mortality in women worldwide.[1,2] In clinical practice, individual specific targeted therapy has attracted more and more attention
Note: coef: the coefficient of Long non-coding RNAs (lncRNAs) correlated with survival; HR: hazard ratio; HR.95L: low 95% CI of HR; HR.95H: high 95% CI of HR
To further assess whether the 11 autophagy-related lncRNAs participated in the development of breast cancer, we investigated the association of the expression of the 11 autophagy-related lncRNAs with clinicopathological factors
Summary
Breast cancer is the most frequent malignancy and the leading cause of cancer-associated mortality in women worldwide.[1,2] In clinical practice, individual specific targeted therapy has attracted more and more attention. Autophagy is a highly conserved process to maintain cellular homeostasis by lysosomal degradation system.[3] Autophagy plays. | 5 a crucial role in many physiological processes and various pathological events, including stress and starvation adaptation, metabolism, inflammation, neurodegenerative disorders and cancer.[4,5,6,7] Over the past few years, an increasing number of studies have indicated that autophagy participates in the development and progression of breast cancer.[8,9] identifying key regulators of autophagy is of great importance for both theoretical basis and clinical practice
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
