Abstract
BackgroundGestational diabetes mellitus (GDM) is a growing global epidemic. Our study aims to confirm the association between circulatory coiled-coil domain-containing 80 (CCDC80) in pregnant women with GDM, to investigate the discriminatory power of CCDC80 on GDM, and to explore the relationships between this molecular level and clinical cardiometabolic parameters.MethodsA 1:2 matched case-control study with 61 GDM patients and 122 controls was conducted using a propensity score matching protocol. All participants were screened from a multicenter prospective pre-birth cohort: Born in Shenyang Cohort Study (BISCS). During 24 and 28 weeks of gestation, follow-up individuals underwent an oral glucose tolerance test (OGTT) and blood sampling for cardiometabolic characterization.ResultsFollowing propensity score matching adjustment for clinical variables, including maternal age, gestational age, body mass index, SBP and DBP, plasma CCDC80 levels were significantly decreased in patients with GDM when compared with controls (0.25 ± 0.10 vs. 0.31 ± 0.12 ng/ml, P = 0.003). Conditional multi-logistic regression analyses after adjustments for potential confounding factors revealed that CCDC80 was a strong and independent protective factor for GDM (ORs < 1). In addition, the results of the ROC analysis indicated the CCDC80 exhibited the capability to identify pregnant women with GDM (AUC = 0.633). Finally, multivariate regression analyses showed that CCDC80 levels were positively associated with AST, monoamine oxidase, complement C1q, LDL-C, apolipoprotein A1and B, and negatively associated with blood glucose levels at 1 h post- OGTT.ConclusionsBiomarker CCDC80 could be of great value for the development of prediction, diagnosis and therapeutic strategies against GDM in pregnant women.
Highlights
Gestational diabetes mellitus (GDM) is a growing global epidemic
Before propensity score matching (PSM), maternal age, weight, body mass index (BMI), fasting blood glucose (FBG), oral glucose tolerance test (OGTT) 1 h, OGTT 2 h and blood pressure was significantly higher in the GDM group than that in the control group
With the use of PSM, there were no significant differences in maternal age, weight, BMI status and blood pressure status between two groups
Summary
Gestational diabetes mellitus (GDM) is a growing global epidemic. Our study aims to confirm the association between circulatory coiled-coil domain-containing 80 (CCDC80) in pregnant women with GDM, to investigate the discriminatory power of CCDC80 on GDM, and to explore the relationships between this molecular level and clinical cardiometabolic parameters. Gestational diabetes mellitus (GDM) refers to impaired glucose tolerance with onset or found for the first time in the second or third trimester of gestation, which is a common metabolic disturbance during pregnancy [1, 2]. Adipocytes serve as sites of lipids deposition but can secrete diverse mediators through autocrine, paracrine or endocrine mechanisms, referred to as adipocyte-secreted proteins or adipokines These released proteins play pivotal functions in energy homeostasis, insulin sensitivity and systemic inflammation [13]. Li et al found that serum CCDC80 was negatively correlated with fasting blood glucose (FBG) in overweight and obesity subjects [19] Whether this molecular is linked to the risk of GDM in pregnant women is less clear
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