A novel approach to resolve cellular volume responses to an anisotonic challenge.

Abstract

The ability of cells to regulate their volume in response to a change in external osmolality can be essential to the maintenance of their normal function. In the case of corneal epithelial cells, changes in tear film osmolarity can occur in daily living because of potential exposure to the drying effect of wind, fresh or salt water, etc. Such changes can lead to alterations in epithelial cell volume that affect cell function. For some cells, the inability to undergo volume regulation contributes to rapid cell death.1 KeywordsRegulatory Volume DecreaseEhrlich Ascites Tumor CellRapid Cell DeathOsmotic ResponseHypotonic ChallengeThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.