Abstract
BackgroundThe aim of this study was to evaluate the early anti-tumor efficiency of different therapeutic agents with a combination of multi-b-value DWI, DCE-MRI and texture analysis.MethodsEighteen 4 T1 homograft tumor models were divided into control, paclitaxel monotherapy and paclitaxel and bevacizumab combination therapy groups (n = 6) that underwent multi-b-value DWI, DCE-MRI and texture analysis before and 15 days after treatment.ResultsAfter treatment, the tumors in the control group were significantly larger than those in the combination group (P = 0.018). In multi-b-value DWI, the ADCslow obviously increased in the combination group compared to that in the others (P < 0.01). The f increased in the control and paclitaxel groups, but the combination group showed a significant decrease versus the others (P < 0.02). Additionally, in DCE-MRI, the decreasing Ktrans showed an evident difference between the combination and control groups (P = 0.003) due to the latter’s increasing Ktrans. The intra-group comparisons of tumor texture in pre-, mid- and post-treatments showed that the entropy had all significantly increased in all groups (P < 0.01, SSF = 0–6), though the MPP, mean and SD increased only in the combination group (PMPP,mean,SD < 0.05, SSF = 4–6). Moreover, the inter-group comparisons revealed that the mean and MPP exhibited significant differences after treatment (Pmean,MPP < 0.05, SSF = 0–3).ConclusionAll these results suggest some strong correlations among DWI, DCE and texture analysis, which are beneficial for further study and clinical research.
Highlights
The aim of this study was to evaluate the early anti-tumor efficiency of different therapeutic agents with a combination of multi-b-value diffusion-weighted imaging (DWI), dynamic contrast-enhanced MRI (DCE-MRI) and texture analysis
The murine breast cancer cell line 4 T1 was obtained from the Cell Bank of the Chinese Academy of Science (Beijing, China) and maintained in Dulbecco’s minimum essential medium (DMEM) supplemented with 10% fetal bovine serum, penicillin (100 units/ml) and streptomycin (100 units/ml) and incubated at 37 °C in a 5% CO2 air environment
The growth of 4 T1-tumors in these three groups showed no conspicuous differences on day 7 after therapy
Summary
The aim of this study was to evaluate the early anti-tumor efficiency of different therapeutic agents with a combination of multi-b-value DWI, DCE-MRI and texture analysis. Using the characteristics of lesions, fMRI provides real-time and non-destructive measurements of pathological processes in vivo for early diagnosis and therapy evaluation. The two types of novel fMRI scanning techniques, multi-b-value diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI), can potentially detect major diseases such as breast cancer. Antiangiogenic therapy is considered a highly promising new strategy to prevent tumor growth and metastasis. These two functional MRI techniques are able to measure the microvascular structure and reflect its permeability [2]. Several qualitative and semiquantitative parameters of DCE-MRI, ranging from simple semiquantitative inspection of the time-intensity curves to more sophisticated tracer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
