Abstract
The aim of this article was to choose the optimal ingredients for oral disintegrating tablets of bambuterol hydrochloride (BBH) and use a novel approach to measure disintegration time. The disintegration time measured by a new approach was compared with disintegration time measured in oral cavity and conventional disintegration test. The result shows that the new apparatus is suitable for measuring the disintegration time. The effect of ingredients (diluents, disintegrants and adhesives) on the characteristics of the tablets was investigated. The orally disintegrating tablets of BBH were prepared by wet granulation. The results showed that the optimum proportion was 10 mg BBH, 100 mg lactose, 80 mg MCC, 10 mg crospovidone (PVPP), 2 mg aspartame, 2 mg DL-malic acid. The orally disintegrating tablet disintegrated rapidly, tasted good and could be taken convenient.
Highlights
Because of lifestyle changes, a demand has arisen for the development of pharmaceutical forms that can be readily handled and taken by many patients
Disintegration Time (DT) is an important coefficient to orally disintegrating tablets
Sucrose, mannitol and starch are used as diluents in or dissolving tablets (ODTs)
Summary
A demand has arisen for the development of pharmaceutical forms that can be readily handled and taken by many patients. Numerous studies on various compositions and manufacturing methods of orally disintegrating or dissolving tablets (ODTs) have been performed [5,6]. DT is an important coefficient to orally disintegrating tablets. ODTs disintegrate more quickly and need less solution. In this study we want to choose the optimal ingredients for oral disintegrating tablets of bambuterol hydrochloride (BBH) and use a novel approach to measure disintegration time.
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