A Novel Approach on Nanosphere Based Colon Targeted Drug Delivery System

Abstract

Oral route is the most feasible and desired one, CDDS may also employ alternative methods. When administering medications directly to the colon, rectal administration is the fastest method. Rectal administration makes it challenging to reach the proximal portion of the colon. Rectal administration may potentially cause patients discomfort and result in poor compliance. Particles with a diameter between 10 and 200 nm are known as nanospheres. Nanospheres can be crystalline or amorphous in form, and they can shield a medicine from enzymatic and chemical deterioration. When treating colonic illness, targeted drugdelivery to the colon ensures direct therapy at the afflicted area with a lower dose and less systemic adverse effects and provides an appropriate environment for proteins and peptides that are susceptible to gastric fluid and digestive enzymes. It also minimizes the first pass metabolism advantage of the standard dose form and prevents gastrointestinal discomfort brought on by the ingestion of NSAIDs.
 Keywords: Nanospheres, CDDS, Nanoparticles, NSAID, gastrointestinal discomfort