A Novel Approach of Curcumin Loaded Chitosan/Dextran Nanocomposite for the Management of Complicated Abdominal Wound Dehiscence

Abstract

In recent times, about 35% of patients suffered from post laparotomy wound dehiscence and the effective management of wound is highly inevitable. Natural polymers such as chitosan and dextran have excellent biodegradability and biocompatibility. These features make them an ideal candidate for biomedical applications. The present study is aimed to synthesize curcumin loaded chitosan/dextran nanocomposite and to evaluate its antibacterial and abdominal wound healing properties. The curcumin loaded chitosan/dextran nanocomposite was characterized by UV–vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Zeta potential. FTIR results inferred the strong interaction between the three components. The surface morphology of curcumin loaded chitosan/dextran nanocomposite was spherical shaped which are firmly anchored on the polymer matrix. TEM analysis also confirmed the formation of the composite. The XRD analysis confirmed the presence of crystalline material. The curcumin loaded chitosan/dextran nanocomposite recorded greater antibacterial effects on S. mutans and E. coli. The number of dead bacterial cells was significantly higher in curcumin loaded chitosan/dextran nanocomposite. Moreover, curcumin loaded chitosan/dextran nanocomposite stimulated the regeneration of new tissues and promoted the wound healing efficiency in the mouse. Therefore, the developed materials have a potential role as antimicrobial and abdominal wound healing in biomedical fields.