Abstract
A novel approach in studies of the posttranslational modification effect on YB-1 translocation
Highlights
A novel approach in studies of the posttranslational modification effect on Y-box binding protein 1 (YB-1) translocation
The Y-box binding protein 1 (YB-1) is a multifunctional protein. It is involved in mRNA translation and stabilization, while in the nucleus it participates in replication regulation and DNA transcription
If phosphorylation inhibits the transition, the phosphomimetic mutant will be detected in the cytoplasm in stimulating conditions, while the dephosphorylated one will localize to the nucleus under standard conditions
Summary
A novel approach in studies of the posttranslational modification effect on YB-1 translocation It is involved in mRNA translation and stabilization, while in the nucleus it participates in replication regulation and DNA transcription. YB-1 shows the cytoplasmic localization, but in some cases (under stress or modification) it goes to the nucleus. Its best studied nuclear translocation-causing modification is phosphorylation at S102.
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