A Novel Approach for Classification of Schizophrenia Patients and Healthy Subjects Using Auditory Oddball Functional MRI

Abstract

Schizophrenia is a serious psychiatric illness which needs early and accurate diagnosis. Difference in activation patterns of schizophrenia patients and healthy subjects can be identified with the help of functional magnetic resonance imaging (fMRI). However, manual diagnosis using fMRI depends on subjective observation and may be erroneous. This has motivated the pattern recognition and machine learning research community to develop a reliable and efficient decision model for classification of schizophrenia patients and healthy subjects. However, high dimensionality and low availability of fMRI data leads to the curse-of-dimensionality problem which may degrade the performance of decision model. In the present research work, a combination of feature extraction and feature selection techniques is utilised to obtain a reduced set of relevant and non-redundant features for classification of schizophrenia patients and healthy subjects. Features are extracted from pre-processed fMRI data using a general linear model approach. Next Fisher's discriminant ratio, a univariate method, is employed for feature selection i.e. To determine a subset of discriminative features. Further, minimum Redundancy Maximum Relevance (mRMR) feature selection, a multivariate method, is employed to obtain a set of relevant and non-redundant features which are used for learning a decision model using support vector machine. Two balanced and well-age matched datasets of auditory oddball task derived from a publicly available multisite FBIRN dataset are used for experiments. First dataset consists of fMRI scans of 34 schizophrenia patients and 34 healthy subjects acquired through 1.5 Tesla scanners while second dataset consists of 25 schizophrenia patients and 25 healthy subjects acquired through 3 Tesla scanners. The performance is evaluated in terms of sensitivity, specificity and classification accuracy, and compared with two well-known existing approaches for classification of schizophrenia patients and healthy subjects using fMRI. Experimental results demonstrate that the proposed model outperforms the existing approaches in terms of sensitivity, specificity and classification accuracy. The proposed approach achieves classification accuracy of 88.2% and 78.0% for 1.5 Tesla and 3 Tesla datasets respectively. In addition, the brain regions containing the discriminative features are identified which may be potential biomarkers for diagnosis of schizophrenia using fMRI.