Abstract
Lung cancer is the leading cause of cancer-related death in both men and women. Lung cancer contains a small population of cancer cells with stem-like features known as cancer stem cells (CSCs). CSCs are often more resistant to current therapeutic treatments. Thus, it is urgent to develop a novel agent that is able to inhibit CSCs growth. In this study, we examined the ability of SNG1153, a novel chemical agent to inhibit the growth of lung CSCs. We found that SNG1153 inhibited growth and induced apoptosis in established lung cancer cells. We also found that SNG1153 inhibited the tumorsphere formation and decreased CD133-positive (lung CSC marker) cancer cells. SNG1153 was able to attenuate tumor formation in NOD/SCID (non-obese diabetic/severe combined immunodeficient) mice injected with lung tumorsphere cells. We further demonstrated that SNG1153 induced β-catenin phosphorylation and down-regulated β-catenin. Our results thus demonstrate that SNG1153 effectively inhibits the growth of lung CSCs and suggest that SNG1153 may be a novel therapeutic agent to treat human lung cancer.
Highlights
Human lung cancer is the most common cause of cancer-related mortality in the world and affects more than one million people yearly [1, 2]
We found that SNG1153 inhibited growth and induced apoptosis in established lung cancer cells
We found that SNG1153 effectively inhibited the growth of H460 cells in a dose-dependent manner (Figure 1B)
Summary
Human lung cancer is the most common cause of cancer-related mortality in the world and affects more than one million people yearly [1, 2]. CSCs are a small subpopulation of undifferentiated cells within tumors that are responsible for tumor initiation, maintenance, and metastasis [3,4,5]. CSCs have been identified in various human tumors, such as breast, brain, prostate, pancreatic, colon and lung cancers [1, 3, 6,7,8,9,10,11]. CSCs-enriched cancer cell populations form tumorsphere in low-adherence culture in vitro [12, 13] and exhibit the ability to form tumors at limiting dilutions in vivo [1]. Distinct markers have been identified for purification of cancer stem cells, such as CD133, CD44high/CD24low, ABCG2, ALDH-1 [1, 6, 7, 9, 11, 14,15,16,17]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
