A novel and efficient synthesis of 1, 2, 3,4-tetrahydropyrimidine carboxamide derivatives by Biginelli reaction and their in vitro antibacterial activity

Abstract

Introduction and Aim: An efficient aspect of two step synthesis of tetrahydro pyrimidine carboxamide derivatives were developed by Biginelli reaction. The two-step synthesized 1,2,3,4-tetrahydropyrimidinecarboxamide compounds were evaluated by In-vitro studies like antifungal and bacterial activities. Few compounds were shown excellent zone of inhibition against fungal and Microbial activities. In this study showed significant effect of antifungal and bacterial action against tetrahydro pyrimidine derivatives. Materials and Methods: In this procedure to synthesize 1,2,3,4-tetrahydropyrimidinecarboxamide derivatives, ethyl acetoacetate, cytosine, para-toluene sulphonic acid and ethanol were used. Results: The synthesized compounds of 1,2,3,4-tetrahydropyrimidine carboxamide derivatives through Biginelli reaction used an efficient catalyst such as para-toluene sulphonic acid and solvent ethanol. In this study tested compounds have developed into two step protocol for synthesis of diversely substituted novel pyrimidines. Conclusion: In this study the synthesized 1,2,3,4-tetrahydropyrimidine carboxamide (THPC) shows significant inhibiting action against Gram +ve, Gram –ve bacterial and fungal growth.