Abstract
Peroxynitrite is a strong oxidant formed by the reaction of a superoxide anion radical and nitric oxide. It plays an important role in inducing apoptosis, damaging the mitochondrial respiratory chain and causing the occurrence of nitrotyrosine in cortical neurons. We have demonstrated that 5-hydroxytryptamine (5-HT) does not inhibit peroxynitrite formation by 3-morpholinosydnonimine with the release of a superoxide anion radical and nitric oxide, however, it does markedly scavenge peroxynitrite itself. 5-HT is directly involved in the scavenging of peroxynitrite, and might play a role in retarding the development of brain disease.
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